The United States has described the strike – which killed dozens, including the besieged city’s last paediatrician – as “reprehensible”.
Russia is being urged to exert its influence over the Assad Government to stop the attacks.
There was chaos and panic on the streets of Aleppo as a hospital supported by international charity, Doctors Without Borders, was bombarded.
“What wrong did we do?” one little girl asks as she trudges through the rubble.
It’s the latest deadly attack as fighting resumes on both sides of the city after the collapse of peace talks.
The apparent targeting of a key medical centre and surrounding buildings has sparked outrage.
Medecins Sans Frontiers director Joan Tubau has revealed the airstrike claimed the life of the city’s last paediatrician.
But despite the danger, Mr Tubau says the international charity will continue trying to provide health care for needy Syrians.
“Our position of course, is a position of outrage and profound condemnation. It cannot be admitted that a fully functional medical facility in the middle of war, taking care of the most vulnerable, is hit as a result of a military action. Our position is of absolute outrage and condemnation of this attack.”
Those frank sentiments have been echoed in Washington by President Barack Obama’s spokesman, Josh Earnest.
“These tactics are abhorrent, they’re immoral but unfortunately they’re entirely consistent with the actions that we’ve seen from the Assad regime for quite some time. This does place even more pressure on an already fragile cessation of hostilities. And it’s the continued violation of that cessation hostilities by the Assad regime and supporting forces that is also having a negative impact on the political talks”
The US State Department’s John Kirby is in no doubt where responsiblity lies, given the way the attack was carried out.
“Details and the circumstances of the attack are still coming in but it sure bears all the hallmarks of the kinds of strikes that the regime has done in the past on treatment facilities and, frankly, on first responders. We continue to call on and urge Russia to use its influence on the Assad regime to bring these kind of strikes to an end.”
International pressure is mounting on all parties.
United Nations Special Envoy for Syria, Staffan de Mistura, has called on Russia and the US to revive peace talks, which came to a halt in Geneva after the Syrian Opposition pulled out most of its delegates.
But the envoy says real progress can only be made with a ceasefire.
“It will be not difficult for everyone to come back around the table. How can you have substantial talks when you have only news about bombing and shelling? It’s something that even I find difficult. Can you imagine the Syrians?”
For civilians in Aleppo, the situation has been described as “catastrophic” .
Chairman of the United Nations Humanitarian Taskforce, Jan Egeland, has warned the latest violence could wipe out four months of progress in getting aid to Syrians in beseiged areas.
“The stakes are so incredibly high because so many civilian lives are at stake. So many humanitarian health workers and relief workers are being bombed, killed, maimed at the moment. What we basically see is that while people are bleeding, the health workers are unable to do their work.”
And that is threatening a crucial lifeline to potentially millions of desperate people.